СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О РОЛИ СИСТЕМ РЕПАРАЦИИ КЛЕТОК В ОБЕСПЕЧЕНИИ СТАБИЛЬНОСТИ И НАДЕЖНОСТИ ГЕНОМА
Ключові слова:
стабільність геному, репарація, рекомбінація, хроматинАнотація
В еукаріотичних клітинах спадкування як точної послідовності ДНК, так і її організації в хроматин, є критичним для підтримки стабільності геному. Різні пошкодження ДНК, викликані ендо- і екзогенними факторами, створюють проблему для підтримки цієї стабільності. Для повного розуміння, як клітини можуть впоратися з цим завданням, необхідно інтегрувати знання про природу цих пошкоджень, їх виявлення і репарації всередині хроматінового оточення.Посилання
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